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Fixation of Functionalized DNA Nanostructures

Erik Lundberg (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
Göteborg : Chalmers University of Technology, 2009.
[Licentiatavhandling]

This thesis features results from two different studies on a fully addressable non-repetitive network on the nanometre scale, assembled by synthetic DNA molecules. A bio-inspired molecular approach, based on principles of self-assembly, has brought about a paradigm shift in nanoscience, from a top-down to a bottom-up perspective. The studied system in this thesis is a two-dimensional assembly of hexagonal unit cells with the potential of controlling diverse processes, such as energy transfer or chemical synthesis, at the highest precision. The first study proves successful formation of the first generation of this network, a fused bihexagonal structure. The study also illustrates a method of addressing a specific location in the system using triplex recognition. Furthermore, the triplex recognition functions in principle as an information storage device. The second study introduces a fixation strategy based on the principles of click chemistry. By covalently cross-linking a DNA hexagon the stability is markedly increased, creating a module that may readily be adapted as a building block for larger structures.

Nyckelord: dna, nanotechnology, self-assembly, click chemistry, triplex recognition, cross-linking, fixation, spectroscopy, gel electrophoresis, fret



Denna post skapades 2009-10-06.
CPL Pubid: 99802

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)

Ämnesområden

Kemiteknik

Chalmers infrastruktur

Examination

Datum: 2009-10-27
Tid: 10:15
Lokal: 10:an, Kemihuset, Chalmers tekniska högskola

Ingår i serie

Licentiatuppsatser vid Institutionen för kemi- och bioteknik, Chalmers tekniska högskola