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An accurate model for genetic hitchhiking

Anders Eriksson ; Pontus Fernström ; Bernhard Mehlig ; Serik Sagitov (Institutionen för matematiska vetenskaper, matematisk statistik)
Genetics (0016-6731). Vol. 178 (2008), 1, p. 439-451.
[Artikel, refereegranskad vetenskaplig]

We suggest a simple deterministic approximation for the growth of the favored-allele frequency during a selective sweep. Using this approximation we introduce an accurate model for genetic hitchhiking. Only when Ns < 10 (N is the population size and s denotes the selection coefficient) are discrepancies between our approximation and direct numerical simulations of a Moran model notable. Our model describes the gene genealogies of a contiguous segment of neutral loci close to the selected one, and it does not assume that the selective sweep happens instantaneously. This enables us to compute SNP distributions on the neutral segment without bias.

Nyckelord: sampling formula, selective sweeps, recombination, signature, polymorphism, genealogies, evolution, alleles

Denna post skapades 2009-09-04. Senast ändrad 2016-07-11.
CPL Pubid: 97370


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Institutioner (Chalmers)

Institutionen för fysik (GU) (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)



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