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Metabolic footprinting in microbiology: methods and applications in functional genomics and biotechnology

Valeria Mapelli ; Lisbeth Olsson (Institutionen för kemi- och bioteknik, Industriell Bioteknik ) ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Trends in Biotechnology Vol. 26 (2008), 9, p. 490-497.
[Artikel, refereegranskad vetenskaplig]

Metabolomics embraces several strategies that aim to quantify cell metabolites in order to increase our understanding of how metabolite levels and interactions influence phenotypes. Metabolic footprinting represents a niche within metabolomics, because it focuses on the analysis of extracellular metabolites. Although metabolic footprinting represents only a fraction of the entire metabolome, it provides important information for functional genomics and strain characterization, and it can also provide scientists with a key understanding of cell communication mechanisms, metabolic engineering and industrial biotechnological processes. Due to the tight and convoluted relationship between intracellular metabolism and metabolic footprinting, metabolic footprinting can provide precious information about the intracellular metabolic status. Hereby, we state that integrative information from metabolic footprinting can assist in further interpretation of metabolic networks.



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Denna post skapades 2009-03-19. Senast ändrad 2015-03-30.
CPL Pubid: 91679

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Industriell Bioteknik (2008-2014)
Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)

Ämnesområden

Livsvetenskaper
Industriell bioteknik

Chalmers infrastruktur