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Fine mapping study in Scandinavian families suggests association between coeliac disease and haplotypes in chromosome region 5q32.

Svetlana Adamovic ; S. S. Amundsen ; Benedicte Alexandra Lie ; Åsa Hellqvist ; Audur Gudjonsdottir ; Johan Ek ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Jan Wahlström ; Henry Ascher ; Ludvig M Sollid ; Åsa Torinsson Naluai
Tissue Antigens (1399-0039). Vol. 71 (2008), 1, p. 27-34.
[Artikel, refereegranskad vetenskaplig]

The previous genome-wide scan in Scandinavian families supported earlier evidence for linkage of a region on chromosome 5 (5q31–33) to coeliac disease. This study deals with further genetic mapping of an 18 cM region, spanning from marker GAh18A (131.87 Mb) to D5S640 (149.96 Mb). Linkage and association analyses were performed in a two-step approach. First, seven microsatellites were added. Strong evidence for linkage was obtained with a Zlr score of 3.96, Pnc = 4 × 10−5 at marker D5S436. The strongest association was with a haplotype consisting of the markers D5S2033 and D5S2490 (Pnc < 0.001). In the second step, we added 17 microsatellites and 69 single nucleotide polymorphisms (SNPs) to the analysis. These markers were located close to or within candidate genes across the region of approximately 7 Mb beneath the linkage peak marked by D5S2017 and D5S812. A substantial increase of the linkage signal with a maximum Zlr score of 4.6 at marker rs1972644 (Pnc = 2 × 10−6) was obtained and several SNPs showed association. Seven SNPs that individually showed the strongest association were genotyped in a second independent family sample set (225 trios). In the trio family sample as well as in the multiplex family sample, the strongest association was found with SNPs within the region flanked by the associated microsatellites D5S2033 and D5S2490 at 5q32.

Nyckelord: autoimmunity, coeliac disease, complex diseases, genetic association, human leucocyte antigen, 5q31–33



Denna post skapades 2008-12-23. Senast ändrad 2015-01-16.
CPL Pubid: 82767

 

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Institutioner (Chalmers)

Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik (GU)
Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)

Ämnesområden

Molekylärbiologi

Chalmers infrastruktur