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Signal frequency studies of an environmental application of a 65 nm region ion sensitive field effect transistor sensor

K. Risveden ; S. Bhand ; J. F. Ponten ; T. Anden ; Nils Calander (Institutionen för mikroteknologi och nanovetenskap, Fysikalisk elektronik) ; M. Willander ; B. Danielsson
Sensors and actuators. B, Chemical (0925-4005). Vol. 127 (2007), 1, p. 198-203 .
[Artikel, refereegranskad vetenskaplig]

A rapid and sensitive novel type of bioelectronic Region Ion Sensitive Field Effect Transistor (RISFET) nanosensor was constructed on a chip with a 65 nm sensing electrode gap. The RISFET nanosensor was demonstrated for the environmental pesticide analysis of neurotoxic organocarbamate/carbofuran. The linear range for carbofuran analysis is ac signal frequency dependent, studied in the range (500 down-0.5 Hz, 50 mV(peak-peak) ac) and a bias voltage applied between the bottom capacitor plate and the electrodes. The signal current response is measured using a low-noise pico ammeter. The inhibition of acetylcholinesterase (AChE) by carbofuran was detectable in a logarithmic linear range (0.1-100nM) at 1.08 Hz, with a lower limit of detection of inhibition 0.1 nM with 10 min incubation time. The sensor is based on the principle of focusing charged reaction products with an electrical field in a region between the sensing electrodes. The current measurement by the sensor electrodes is correlated to the composition of the sample. The carbofuran detection is based on the ability to inhibit the enzyme AChE. The RISFET sensor chip is fabricated using conventional electron beam lithography. The encompassed sensor volume in the "nanocell" is in the attoliter range. (c) 2007 Elsevier B.V. All rights reserved.

Special Issue: Eurosensors XX The 20th European Conference on Solid-State Transducers, the 20th European conference on Solid-State Transducers

Denna post skapades 2008-12-19. Senast ändrad 2016-09-30.
CPL Pubid: 82318


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Institutioner (Chalmers)

Institutionen för mikroteknologi och nanovetenskap, Fysikalisk elektronik (2007-2010)



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