CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Evolutionary conservation of human drug targets in organisms used for environmental risk assessments.

Lina-Maria Gunnarsson ; Alexandra Jauhiainen (Institutionen för matematiska vetenskaper) ; Erik Kristiansson ; Olle Nerman ; D. G. Joakim Larsson
Environmental science & technology (0013-936X). Vol. 42 (2008), 15, p. 5807-13.
[Artikel, refereegranskad vetenskaplig]

Pharmaceuticals are typically found in very low concentrations in the aquatic environment. Accordingly, environmental effects clearly assigned to residual drugs are consistent with high affinity interactions with conserved targets in affected wildlife species rather than with a general toxic effect. Thus, evolutionarily well-conserved targets in a given species are associated with an increased risk. In this study orthologs for 1318 human drug targets were predicted in 16 species of which several are relevant for ecotoxicity testing. The conservation of different functional categories of targets was also analyzed. Zebrafish had orthologs to 86% of the drug targets while only 61% were conserved in Daphnia and 35% in green alga. The predicted presence and absence of orthologs agrees well with published experimental data on the potential for specific drug target interaction in various species. Based on the conservation of targets we propose that aquatic environmental risk assessments for human drugs should always include comprehensive studies on aquatic vertebrates. Furthermore, individual targets, especially enzymes, are well conserved suggesting that tests on evolutionarily distant organisms would be highly relevant for certain drugs. We propose that the results can guide environmental risk assessments by improving the possibilities to identify species sensitive to certain types of pharmaceuticals or to other contaminants that act through well defined mechanisms of action. Moreover, we suggest that the results can be used to interpret the relevance of existing ecotoxicity data.



Denna post skapades 2008-11-18. Senast ändrad 2014-04-29.
CPL Pubid: 78289

 

Läs direkt!


Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi (GU)
Institutionen för matematiska vetenskaperInstitutionen för matematiska vetenskaper (GU)
Zoologiska institutionen (1954-2011)

Ämnesområden

Kemi
Mikrobiologi
MEDICIN OCH HÄLSOVETENSKAP

Chalmers infrastruktur

Relaterade publikationer

Denna publikation ingår i:


Statistics in Gene Expression, Metabolomics, and Comparative Genomics in Evolution