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Effects of inflammation on cerebral electric activity in fetal sheep

Magnus Thordstein ; Ingemar Kjellmer ; Nils Löfgren ; Johan Löfhede (Institutionen för signaler och system, Medicinska signaler och system) ; Kaj Lindecrantz (Institutionen för signaler och system, Medicinska signaler och system) ; Justin M Dean ; Carina Mallard
2nd Congress of the European Academy of Paediatrics, Nice 23-28 okt 2008 (2008)
[Konferensbidrag, poster]

OBJECTIVE
Intrauterine infections can by themselves induce fetal brain damage but also potentiate the effects of other harmful influences such as asphyxia and seizures. Using an EEG technique that permits the recording of extremely low frequencies, often called DC EEG, changes in the level, i.e. DC shifts can be detected. The DC level has been suggested to depend mainly on the potential over the blood brain barrier (BBB), in turn decided primarily by the arterial level of pCO2. Fetuses affected by infection/inflammation that produce detrimental effects on the brain, may have elevated levels of pCO2 and disturbance of the BBB. We aimed at investigating the possibility that the DC EEG could be used to detect the effects of inflammation on the fetal brain.

METHODS
Fetal sheep were instrumented at 97 days of gestation with catheters, four active EEG electrodes placed on the dura mater as well as extracranial reference and ground electrodes. After three days of recovery, the bacterial endotoxin lipopolysaccharide (LPS) was given to the fetus (200 ng i.v.).

RESULTS
Exposure to LPS induced a positive DC shift in parallel to the assumed affection of cerebral function and to the pCO2 elevation. This change was not always obvious in standard EEG.

CONCLUSIONS
These recordings of fetal DC EEG appear to be the first to be done. They indicate that the effects of inflammation on cerebral function can be monitored by DC EEG. Such monitoring might be feasible also during late stages of labour and in neonates.



Denna post skapades 2008-11-14. Senast ändrad 2010-01-26.
CPL Pubid: 77893

 

Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (2006-2016)
Institutionen för signaler och system, Medicinska signaler och system
Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi (GU)

Ämnesområden

Signalbehandling
Medicinsk teknik
Klinisk neurofysiologi

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