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Use of ordered mesoporous materials as tools for organic and bioorganic synthesis

Paul Handa (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Tomasz Witula (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Pedro Reis (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Krister Holmberg (Institutionen för kemi- och bioteknik, Teknisk ytkemi ; Kompetenscentrum katalys (KCK))
ARKIVOC (1551-7004). 6, p. 107-118. (2008)
[Artikel, refereegranskad vetenskaplig]

Ordered mesoporous materials are materials with well defined pore sizes in the range of 2 to 50 nm. This paper shows that suspensions of particles of mesoporous materials can be useful tools for organic and bioorganic synthesis. They can be used to overcome reactant incompatibility, as is demonstrated for a reaction between 4-tert-butylbenzyl bromide and KI. The pores are impregnated with an aqueous solution of KI and the lipophilic reactant is present in the continuous apolar phase. The reaction occurs at the pore openings. The pores of the mesoporous material can also be used as host for a homogeneous catalyst. The catalyst-loaded particles are kept as a suspension in a medium that contains the reactants. This principle is demonstrated for a Heck-type reaction with a water-soluble rhodium catalyst inserted into the pores of mesoporous silica. It is also shown to work well for a 1,4-conjugate addition between two water-soluble reactants, 4-carboxyphenylboronic acid and methyl acrylate, in which case a toluene-soluble rhodium catalyst was entrapped in the pores of hydrophobized mesoporous silica. The same principle was also used for biocatalysis. Lipase was inserted into either hydrophilic or hydrophobic pores and used for both ester synthesis and ester hydrolysis. Finally, palladium nanoparticles were deposited inside the pores of mesoporous carbon and used as catalyst for a Sonogashira reaction.



Denna post skapades 2008-06-25. Senast ändrad 2016-08-15.
CPL Pubid: 72126

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)
Kompetenscentrum katalys (KCK)

Ämnesområden

Organisk kemi

Chalmers infrastruktur