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**Harvard**

Henningsson, S. och Nilsson, S. (2008) *Detecting two-locus gene-gene effects using monotonisation of the penetrance matrix*.

** BibTeX **

@article{

Henningsson2008,

author={Henningsson, Susanne and Nilsson, Staffan},

title={Detecting two-locus gene-gene effects using monotonisation of the penetrance matrix},

journal={Statistical Applications in Genetics and Molecular Biology},

issn={1544-6115},

volume={7},

issue={1},

abstract={As more genetic loci are genotyped simultaneously and as the interest in effects of combinations of loci increases, the need for more powerful analysis methods is increased. In the present paper we present a method aimed at increasing the power of likelihood ratio tests for case-control studies investigating possible two-locus effects. The method is based on the notion that the expected effect pattern of one locus, as well as the expected pattern of a penetrance matrix representing the effect of two loci, is a monotone one. By using an algorithm for making the estimated penetrance matrix monotone, the alternative hypothesis is restricted to monotone penetrance matrices only. The evaluation of the likelihood ratio tests for several underlying monotone models shows that the power is substantially increased by using a monotone alternative as compared to when an unrestricted alternative is used.},

year={2008},

keywords={genome-wide association, strategies, heterosis, epistasis, models},

}

** RefWorks **

RT Journal Article

SR Print

ID 70801

A1 Henningsson, Susanne

A1 Nilsson, Staffan

T1 Detecting two-locus gene-gene effects using monotonisation of the penetrance matrix

YR 2008

JF Statistical Applications in Genetics and Molecular Biology

SN 1544-6115

VO 7

IS 1

AB As more genetic loci are genotyped simultaneously and as the interest in effects of combinations of loci increases, the need for more powerful analysis methods is increased. In the present paper we present a method aimed at increasing the power of likelihood ratio tests for case-control studies investigating possible two-locus effects. The method is based on the notion that the expected effect pattern of one locus, as well as the expected pattern of a penetrance matrix representing the effect of two loci, is a monotone one. By using an algorithm for making the estimated penetrance matrix monotone, the alternative hypothesis is restricted to monotone penetrance matrices only. The evaluation of the likelihood ratio tests for several underlying monotone models shows that the power is substantially increased by using a monotone alternative as compared to when an unrestricted alternative is used.

LA eng

PMID 18597663

OL 30