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Dynamic microcompartmentalization of giant unilamellar vesicles by sol gel transition and temperature induced shrinking/swelling of poly(N-isopropyl acrylamide)

Martin Markström (Institutionen för kemi- och bioteknik) ; A. Gunnarsson ; Owe Orwar (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Aldo Jesorka (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
Soft Matter (1744-683X). Vol. 3 (2007), 5, p. 587-595.
[Artikel, refereegranskad vetenskaplig]

Giant unilamellar vesicles (GUVs) were microinjected with aqueous solutions of poly(N-isopropyl acrylamide) (PNIPAAm). Temperature-dependent sol-gel phase transitions of the solutions, followed by shrinking and swelling of the resulting hydrogel, were studied in the presence of a variety of co-solutes within the GUV. Reversible formation of a dense, spherical hydrogel structure (compartment) was observed in all cases with defined shrinking/swelling behaviour at temperatures above the lower critical solution temperatures (LCSTs). Nanotube-mediated merging of two vesicles with thus formed compartments resulted in a single GUV with two internalized hydrogel structures. As an application example, we demonstrate how fluorescent nanoparticles can be immobilized in such gel structures.

Denna post skapades 2008-01-08. Senast ändrad 2010-09-02.
CPL Pubid: 64870


Institutioner (Chalmers)

Institutionen för kemi- och bioteknik (2005-2014)
Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)



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