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Investigation of genes coding for inflammatory components in Parkinson's disease.

Anna Håkansson ; Lars Westberg ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Silvia Buervenich ; Andrea Carmine ; Björn Holmberg ; Olof Sydow ; Lars Olson ; Bo Johnels ; Elias Eriksson ; Hans Nissbrandt
Movement disorders : official journal of the Movement Disorder Society (0885-3185). Vol. 20 (2005), 5, p. 569-73.
[Artikel, refereegranskad vetenskaplig]

Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD). Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset. Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon-gamma (IFN-gamma; T874A in intron 1), interferon-gamma receptor 2 (IFN-gamma R2; Gln64Arg), interleukin-10 (IL-10; G1082A in the promoter region), platelet-activating factor acetylhydrolase (PAF-AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM-1; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls. None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL-10 gene promoter was found to be related to the age of disease onset. Linear regression showed a significantly earlier onset with more A-alleles (P = 0.0095; after Bonferroni correction, P = 0.048), resulting in a 5-year delayed age of onset of the disease for individuals having two G-alleles compared with individuals having two A-alleles. The results indicate that the IL-10 G1082A SNP could possibly be related to the age of onset of PD.

Nyckelord: 1-Alkyl-2-acetylglycerophosphocholine Esterase, genetics, metabolism, Age Factors, Alleles, Brain, metabolism, Chemokine CCL2, genetics, metabolism, DNA Primers, genetics, Genotype, Humans, Inflammation, complications, genetics, metabolism, Intercellular Adhesion Molecule-1, genetics, metabolism, Interferon Type II, genetics, metabolism, Interleukin-10, genetics, metabolism, Middle Aged, Parkinson Disease, complications, genetics, metabolism, Polymorphism, Genetic, genetics, Promoter Regions (Genetics), genetics, Receptors, Interferon, genetics, metabolism, Tumor Necrosis Factor-alpha, genetics, metabolism

Denna post skapades 2007-10-25. Senast ändrad 2015-01-16.
CPL Pubid: 57560


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Institutioner (Chalmers)

Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi (1991-2005)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för klinisk neurovetenskap (1991-2005)



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