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Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease.

Anna Håkansson ; Lars Westberg ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Silvia Buervenich ; Andrea Carmine ; Björn Holmberg ; Olof Sydow ; Lars Olson ; Bo Johnels ; Elias Eriksson ; Hans Nissbrandt
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (1552-4841). Vol. 133 (2005), 1, p. 88-92.
[Artikel, refereegranskad vetenskaplig]

The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system and increased levels of IL-6 have been found in patients with Parkinson's disease (PD). It is known that estrogen inhibits the production of IL-6, via action on estrogen receptors, thereby pointing to an important influence of estrogen on IL-6. In a previous study, we reported an association between a G/A single nucleotide polymorphism (SNP) at position 1730 in the gene coding for estrogen receptor beta (ERbeta) and age of onset of PD. To investigate the influence of a G/C SNP at position 174 in the promoter of the IL-6 gene, and the possible interaction of this SNP and the ERbeta G-1730A SNP on the risk for PD, the G-174C SNP was genotyped, by pyrosequencing, in 258 patients with PD and 308 controls. A significantly elevated frequency of the GG genotype of the IL-6 SNP was found in the patient group and this was most obvious among patients with an early age of onset (

Nyckelord: Age of Onset, Alleles, Estrogen Receptor beta, genetics, Gene Frequency, Genetic Predisposition to Disease, genetics, Genotype, Humans, Interleukin-6, genetics, Linkage Disequilibrium, Parkinson Disease, genetics, Polymorphism, Single Nucleotide



Denna post skapades 2007-10-25. Senast ändrad 2015-01-16.
CPL Pubid: 57559

 

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Institutioner (Chalmers)

Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi (1991-2005)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för klinisk neurovetenskap (1991-2005)

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