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Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women.

Hoi-Por Ho ; Lars Westberg ; Kristina Annerbrink ; Marie Olsson ; Jonas Melke ; Staffan Nilsson (Institutionen för matematisk statistik) ; Fariba Baghaei ; Roland Rosmond ; Göran Holm ; Per Björntorp ; Sven Andersch ; Christer Allgulander ; Elias Eriksson
Psychoneuroendocrinology (0306-4530). Vol. 29 (2004), 9, p. 1138-41.
[Artikel, refereegranskad vetenskaplig]

Although genetic factors are known to be important risk factors for panic disorder there is as yet no conclusive data regarding specific gene variants. Prompted by evidence supporting progesterone to influence the pathophysiology of panic disorder, polymorphisms in the progesterone receptor gene, a single nucleotide polymorphism (G331A) and an insertion/deletion polymorphism (PROGINS) were investigated in 72 patients with panic disorder and 452 controls. The frequency of the A-allele of the G331A polymorphism was higher in panic disorder patients than in controls (p = 0.01). When male and female patients were analyzed separately, the association was observed in female patients only (p = 0.0009), with an odds ratio of 3.5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women.

Nyckelord: Chromosomes, Human, Pair 11, genetics, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Panic Disorder, genetics, Polymorphism, Single Nucleotide, genetics, Receptors, Progesterone, genetics, Risk Factors, Sex Factors

Denna post skapades 2007-10-25. Senast ändrad 2015-01-16.
CPL Pubid: 57519


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Institutioner (Chalmers)

Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi (1991-2005)
Institutionen för matematisk statistik (2002-2004)
Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi (1991-2005)
Institutionen för klinisk neurovetenskap (1991-2005)



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