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Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women.

Lars Westberg ; Hoi-Por Ho ; Fariba Baghaei ; Staffan Nilsson (Institutionen för matematisk statistik) ; Jonas Melke ; Roland Rosmond ; Göran Holm ; Per Björntorp ; Elias Eriksson
Clinical endocrinology (0300-0664). Vol. 61 (2004), 2, p. 216-23.
[Artikel, refereegranskad vetenskaplig]

OBJECTIVE: Oestrogen and progesterone are known to influence the release of human prolactin. The present study was undertaken in order to investigate the possible influence of polymorphisms of the genes encoding the oestrogen receptor (ER)alpha, ERbeta and the progesterone receptor (PGR), on prolactin levels in premenopausal women. DESIGN AND MEASUREMENTS: Serum levels of prolactin were measured in the follicular phase of the menstrual cycle. Subjects were genotyped with respect to a TA repeat polymorphism of the ERalpha gene, a CA repeat polymorphism of the ERbeta gene, and two polymorphisms of the PGR gene: one insertion polymorphism (PROGINS) and one single nucleotide polymorphism (G331A). SUBJECTS: A population-based cohort of 270 42-year-old women. RESULTS: The CA repeat polymorphism of the ERbeta gene and the G331A polymorphism of the PGR gene appeared to be associated with prolactin levels. In contrast, we found no evidence for an influence of the PROGINS polymorphism of the PGR gene or the TA repeat polymorphism of the ERalpha gene on the levels of this hormone. CONCLUSIONS: These data suggest that genetic variants of both the ERbeta and the PGR may influence prolactin release.

Nyckelord: Adult, Cohort Studies, DNA Transposable Elements, genetics, Estrogen Receptor alpha, Estrogen Receptor beta, Female, Follicular Phase, blood, Genotype, Humans, Polymorphism, Genetic, genetics, Polymorphism, Single Nucleotide, genetics, Prolactin, blood, Receptors, Estrogen, genetics, Receptors, Progesterone, genetics, Repetitive Sequences, Nucleic Acid, genetics, Smoking, genetics

Denna post skapades 2007-10-25. Senast ändrad 2015-01-16.
CPL Pubid: 57508


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Institutioner (Chalmers)

Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi (1991-2005)
Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi (1991-2005)
Institutionen för matematisk statistik (2002-2004)



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