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A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women.

Jonas Melke ; Lars Westberg ; Staffan Nilsson (Institutionen för matematisk statistik) ; Mikael Landén ; Henrik Söderström ; Fariba Baghaei ; Roland Rosmond ; Göran Holm ; Per Björntorp ; Lars-Göran Nilsson ; Rolf Adolfsson ; Elias Eriksson
Archives of general psychiatry (0003-990X). Vol. 60 (2003), 10, p. 1017-23.
[Artikel, refereegranskad vetenskaplig]

BACKGROUND: The brain neurotransmitter serotonin is known to affect various aspects of human behavior, including personality traits. Serotonin receptor type 3 is a ligand-gated channel encoded by 2 different subunit genes, HTR3A and HTR3B. A polymorphism (C178T) in the 5' region of the HTR3A gene has recently been identified and suggested to be of functional importance. OBJECTIVE: To elucidate the possible association between the C178T polymorphism in the HTR3A gene and personality traits in women. DESIGN: Two independent samples of 35- to 45-year-old Swedish women were recruited using the population register. Sample 1 (n = 195) was assessed via the Karolinska Scales of Personality and the Temperament and Character Inventory; sample 2 (n = 175) was assessed using the latter only. Both samples were genotyped with respect to the C178T polymorphism in the HTR3A gene. The A1596G polymorphism in the same gene was also investigated. RESULTS: A significant association between C178T genotype and the Temperament and Character Inventory factor harm avoidance was observed in sample 1 (corrected for multiple comparisons P =.04); this finding was subsequently replicated in sample 2 (P =.004) (pooled populations: P<.001). In the pooled sample, all harm avoidance subscales were found to be significantly associated with the C178T polymorphism: anticipatory worry (P =.001), fear of uncertainty (P<.001), shyness (P<.001), and fatigability and asthenia (P =.008). In addition, a significant association was found in sample 1 between the C178T polymorphism and the Karolinska Scales of Personality nonconformity factor (corrected P =.002), including the subscales of social desirability (P<.001), indirect aggression (P =.002), verbal aggression (P =.05), and irritability (P<.001). Participants homozygous for the less common T allele (<4%) differed from the remaining women by displaying lower ratings on harm avoidance and nonconformity. CONCLUSION: The C178T polymorphism in the HTR3A gene may affect the personality trait of harm avoidance in women.

Nyckelord: Adult, Cohort Studies, Female, Genotype, Humans, Middle Aged, Personality, classification, genetics, Personality Assessment, Personality Inventory, Polymorphism, Genetic, genetics, Receptors, Serotonin, 5-HT3, genetics, Serine Endopeptidases, genetics, Sweden



Denna post skapades 2007-10-25. Senast ändrad 2015-01-16.
CPL Pubid: 57465

 

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Institutioner (Chalmers)

Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi (1991-2005)
Institutionen för matematisk statistik (2002-2004)
Institutionen för klinisk neurovetenskap, Sektionen för psykiatri (1991-2005)
Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi (1991-2005)

Ämnesområden

MEDICIN OCH HÄLSOVETENSKAP
Psykiatri

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