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Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women.

Lars Westberg ; Jonas Melke ; Mikael Landén ; Staffan Nilsson (Institutionen för matematisk statistik) ; Fariba Baghaei ; Roland Rosmond ; M Jansson ; Göran Holm ; Per Björntorp ; Elias Eriksson
Molecular psychiatry (1359-4184). Vol. 8 (2003), 1, p. 118-22.
[Artikel, refereegranskad vetenskaplig]

Estrogens are known to play a key role in the regulation of various aspects of behavior. In order to study the potential contribution of genetic variation in the estrogen receptor (ER) alpha to specific personality traits, we investigated a repeat polymorphism in the ER alpha gene in 172 42-year-old women who had been assessed using the Karolinska Scales of Personality (KSP). Based on the hypothesis that there is a relationship between the length of a repeat polymorphism and gene function,(1) the alleles were divided into two groups: short and long. In order to elucidate the possible influence of the ER alpha gene on the different aspects of personality measured by means of the KSP, the possible association between this gene and four different factors ('neuroticism', 'psychoticism', 'non-conformity', and 'extraversion') was analysed. 'Neuroticism', 'psychoticism', and 'non-conformity' all appeared to be associated with the ER alpha gene. After correction for multiple comparisons by means of permutation analysis, the associations with the factor 'non-conformity'--including the subscales 'indirect aggression' and 'irritability'--and the factor 'psychoticism'--including the subscale 'suspicion'--remained significant. The results suggest that the studied dinucleotide repeat polymorphism of the ER alpha gene may contribute to specific components of personality.

Nyckelord: Adult, Aggression, physiology, Anxiety, genetics, Dinucleotide Repeats, Estrogen Receptor alpha, Female, Humans, Irritable Mood, physiology, Neurotic Disorders, genetics, Personality, genetics, Polymorphism, Genetic, Receptors, Estrogen, genetics

Denna post skapades 2007-10-25. Senast ändrad 2015-01-16.
CPL Pubid: 57428


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Institutioner (Chalmers)

Institutionen för fysiologi och farmakologi, Avdelningen för farmakologi (1991-2005)
Institutionen för klinisk neurovetenskap, Sektionen för psykiatri (1991-2005)
Institutionen för matematisk statistik (2002-2004)
Institutionen för invärtesmedicin, Avdelningen för lungmedicin och allergologi (1991-2005)



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