CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Desymmetrization of prochiral phosphanes using derivatives of (-)-cytisine

Magnus J Johansson ; Lennart Schwartz ; Mohamed Amedjkouh ; Nina Kann (Institutionen för kemi och biovetenskap)
European Journal of Organic Chemistry 9, p. 1894-1896. (2004)
[Artikel, refereegranskad vetenskaplig]

yHistorically, (-)-sparteine-sec-BuLi has been used to desym-metrize prochiral phosphanes. In this report, derivatives of an alkaloid extracted from the seeds of Laburnum anagyro-ides have been utilized to mimic (+)-sparteine, which is not readily available. In several cases, the enantioselectivities achieved with the (+)-Sparteine surrogates outperformed (-)-sparteine itself in the deprotonation of alkyl-substituted (as well as aryl-substituted) prochiral phosphane derivatives. In addition, use of these surrogates allows a new methodology for a chiral switch in phosphorus chemistry. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).

Nyckelord: asymmetric synthesis, phosphanes, enantioselectivity, sparteine, lithiation, CATALYZED ASYMMETRIC HYDROGENATION, P-CHIRAL DIPHOSPHINES, ENANTIOSELECTIVE HYDROGENATION, PHOSPHINE BORANES, LIGANDS, PHOSPHORUS, STRATEGY



Denna post skapades 2007-10-22. Senast ändrad 2009-10-19.
CPL Pubid: 56007

 

Läs direkt!


Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för kemi (2001-2011)
Institutionen för kemi och biovetenskap (1900-2005)

Ämnesområden

Kemi

Chalmers infrastruktur