CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Bone reaction to nano hydroxyapatite modified titanium implants placed in a gap-healing model

Luiz Meirelles ; Tomas Albrektsson ; Per Kjellin (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Anna Arvidsson ; Victoria Franke Stenport ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Fredrik Currie (Institutionen för kemi- och bioteknik) ; Ann Wennerberg
Journal Biomedical MAterials Research - A (1549-3296). Vol. 87 (2008), 3, p. 624-631.
[Artikel, refereegranskad vetenskaplig]

Nanohydroxyapatite materials show similar chemistry to the bone apatite and depending on the underlying topography and the method of preparation, the nanohydroxyapatite may simulate the specific arrangement of the crystals in bone. Hydroxyapatite (HA) and other CaP materials have been indicated in cases in which the optimal surgical fit is not achievable during surgery, and the HA surface properties may enhance bone filling of the defect area. In this study, very smooth electropolished titanium implants were used as substrata for nano-HA surface modification and as control. One of each implant (control and nano HA) was placed in the rabbit tibia in a surgical site 0.7 mm wider than the implant diameter, resulting in a gap of 0.35 mm on each implant side. Implant stability was ensured by a fixating plate fastened with two side screws. Topographical evaluation performed with an optical interferometer revealed the absence of microstructures on both implants and higher resolution evaluation with AFM showed similar nanoroughness parameters. Surface pores detected on the AFM measurements had similar diameter, depth, and surface porosity (%). Histological evaluation demonstrated similar bone formation for the nano HA and electropolished implants after 4 weeks of healing. These results do not support that nano-HA chemistry and nanotopography will enhance bone formation when placed in a gap-healing model. The very smooth surface may have prevented optimal activity of the material and future studies may evaluate the synergic effects of the surface chemistry, micro, and nanotopography, establishing the optimal parameters for each of them.

Nyckelord: bone defect, nanotopography, nanostructures, hydroxyapatite, osseointegration, in vivo test

Denna post skapades 2007-09-20. Senast ändrad 2012-03-22.
CPL Pubid: 48902


Läs direkt!

Länk till annan sajt (kan kräva inloggning)

Institutioner (Chalmers)

Institutionen för odontologi (GU)
Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi (GU)
Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)
Institutionen för kemi- och bioteknik (2005-2014)
Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för biomaterialvetenskap (GU)



Chalmers infrastruktur