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Synthesis, characterization and screening of biological activity of Zn(II), Fe(II) and Mn(II) complexes with trithiocyanuric acid

Pavel Kopel ; Karel Dolezal ; Libor Machala ; Vratislav Langer (Institutionen för kemi- och bioteknik, Oorganisk miljökemi)
Polyhedron (0277-5387). Vol. 26 (2007), 8, p. 1583-1589.
[Artikel, refereegranskad vetenskaplig]

New Zn(II), Fe(II) and Mn(II) complexes with a combination of nitrogen-donor ligands and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis, IR and UV–Vis spectroscopies. The antitumor activity of the prepared complexes, together with already known Ni(II) species, were assayed in vitro against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukaemia) and MCF-7 (human breast adenocarcinoma) tumor cell lines. The IC50 values of the Fe(II) and Mn(II) compounds turned out to be lower than those of cisplatin and oxaliplatin. The antimicrobial activities were evaluated by MIC against bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis). The molecular structure of [Zn(taa)(ttcH)].H2O (taa = tris(2-aminoethyl)amine) was determined by X-ray diffraction. The central atom is pentacoordinated by four N atoms of taa and one N atom of the ttcH dianion.

Nyckelord: complexes, trithiocyanuric acid, crystal structure, Mössbauer spectra



Denna post skapades 2007-05-01. Senast ändrad 2013-05-29.
CPL Pubid: 41054

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Oorganisk miljökemi (2005-2014)

Ämnesområden

Fasta tillståndets kemi
Bio-oorganisk kemi

Chalmers infrastruktur