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Benzo [a] phenoxazines: A new group of potent P-glycoprotein inhibitors

O. Wesolowska ; J. Molnar ; Gunnar Westman (Institutionen för kemi- och bioteknik, Organisk kemi) ; K. Samuelsson ; M. Kawase ; I. Ocsovszki ; N. Motohashi ; K. Michalak
In Vivo (0258-851X). Vol. 20 (2006), 1, p. 109-113.
[Artikel, refereegranskad vetenskaplig]

The ability of fifteen novel phenoxazine derivatives (four phenoxazines and eleven benzo[a]phenoxazines) to modulate multidrug resistance (MDR) in a P-gp-overexpressing mouse T lymphoma cell line (L5178 MDR) was studied. A flow cytometric functional test, based on the differential accumulation of rhodamine 123 by sensitive and multidrug-resistant cells, was employed. Seven benzo[a]phenoxazines were observed to increase the amount of rhodamine 123 accumulated by resistant cells, i.e. to be new effective MDR modulators. The results allowed us to draw preliminary conclusions about the structural features of benzo[a]phenoxazines which are important for MDR modulation.



Denna post skapades 2007-02-05. Senast ändrad 2016-02-01.
CPL Pubid: 26245

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Organisk kemi (2006-2014)

Ämnesområden

Kemi

Chalmers infrastruktur