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Combining traditional dietary assessment methods with novel metabolomics techniques: present efforts by the Food Biomarker Alliance

Elske M. Brouwer-Brolsma ; Lorraine Brennan ; Christian A. Drevon ; Henk van Kranen ; Claudine Manach ; Lars Ove Dragsted ; Helen M. Roche ; Cristina Andres-Lacueva ; Stephan J. L. Bakker ; Jildau Bouwman ; Francesco Capozzi ; Sarah De Saeger ; Thomas E. Gundersen ; Marjukka Kolehmainen ; Sabine E. Kulling ; Rikard Landberg (Institutionen för biologi och bioteknik, Livsmedelsvetenskap) ; Jakob Linseisen ; Fulvio Mattivi ; Ronald P. Mensink ; Cristina Scaccini ; Thomas Skurk ; Inge Tetens ; Guy Vergeres ; David S. Wishart ; Augustin Scalbert ; Edith J. M. Feskens
PROCEEDINGS OF THE NUTRITION SOCIETY: Nutrition-Society Summer Meeting / Conference on New Technology in Nutrition Research and Practice / Symposium 2 on Use of Biomarkers in Dietary Assessment and Dietary Exposure. Univ Coll Dublin, Dublin, IRELAND. JUL 11-14, 2016 (0029-6651). Vol. 76 (2017), 4, p. 619-627.
[Konferensbidrag, refereegranskat]

FFQ, food diaries and 24 h recall methods represent the most commonly used dietary assessment tools in human studies on nutrition and health, but food intake biomarkers are assumed to provide a more objective reflection of intake. Unfortunately, very few of these biomarkers are sufficiently validated. This review provides an overview of food intake biomarker research and highlights present research efforts of the Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (JPI-HDHL) Food Biomarkers Alliance (FoodBAll). In order to identify novel food intake biomarkers, the focus is on new food metabolomics techniques that allow the quantification of up to thousands of metabolites simultaneously, which may be applied in intervention and observational studies. As biomarkers are often influenced by various other factors than the food under investigation, FoodBAll developed a food intake biomarker quality and validity score aiming to assist the systematic evaluation of novel biomarkers. Moreover, to evaluate the applicability of nutritional biomarkers, studies are presently also focusing on associations between food intake biomarkers and diet-related disease risk. In order to be successful in these metabolomics studies, knowledge about available electronic metabolomics resources is necessary and further developments of these resources are essential. Ultimately, present efforts in this research area aim to advance quality control of traditional dietary assessment methods, advance compliance evaluation in nutritional intervention studies, and increase the significance of observational studies by investigating associations between nutrition and health.

Nyckelord: spectrometry-based metabolomics, nuclear-magnetic-resonance, dried blood spot, mass-spectrometry, fish consumption, meat consumption, vegetable intake, healthy humans, energy-intake, fatty-acids

Denna post skapades 2017-12-28.
CPL Pubid: 254118


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