CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Using metagenomics to investigate human and environmental resistomes

Johan Bengtsson-Palme ; D. G. Joakim Larsson ; Erik Kristiansson (Institutionen för matematiska vetenskaper, Tillämpad matematik och statistik)
Journal of Antimicrobial Chemotherapy (0305-7453). Vol. 72 (2017), 10, p. 2690-2703.
[Artikel, refereegranskad vetenskaplig]

Antibiotic resistance is a global health concern declared by the WHO as one of the largest threats to modern healthcare. In recent years, metagenomic DNA sequencing has started to be applied as a tool to study antibiotic resistance in different environments, including the human microbiota. However, a multitude of methods exist for metagenomic data analysis, and not all methods are suitable for the investigation of resistance genes, particularly if the desired outcome is an assessment of risks to human health. In this review, we outline the current state of methods for sequence handling, mapping to databases of resistance genes, statistical analysis and metagenomic assembly. In addition, we provide an overview of important considerations related to the analysis of resistance genes, and recommend some of the currently used tools and methods that are best equipped to inform research and clinical practice related to antibiotic resistance.



Den här publikationen ingår i följande styrkeområden:

Läs mer om Chalmers styrkeområden  

Denna post skapades 2017-10-16.
CPL Pubid: 252534

 

Läs direkt!


Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för matematiska vetenskaper, Tillämpad matematik och statistikInstitutionen för matematiska vetenskaper, Tillämpad matematik och statistik (GU)

Ämnesområden

Livsvetenskaper
Mikrobiologi

Chalmers infrastruktur