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Bacterial biofilm elimination using gold nanorod localised surface plasmon resonance generated heat

Maria Pihl (Institutionen för kemi och kemiteknik, Teknisk ytkemi) ; E. Bruzell ; Martin Andersson (Institutionen för kemi och kemiteknik, Teknisk ytkemi)
Materials science & engineering. C, biomimetic materials, sensors and systems (0928-4931). Vol. 80 (2017), p. 54-58.
[Artikel, refereegranskad vetenskaplig]

Antimicrobial resistance is an increasing global health concern and the world is facing a major challenge to develop novel ways of replacing antibiotics. Gold nanorods exhibit localised surface plasmon resonance upon optical irradiation. During relaxation, absorbed energy is dissipated as heat, which has been utilized to kill bacteria. In this study, 10 x 45 nm gold nanorods were attached to glass surfaces using silanisation. Then biofilms were cultured on the surfaces and studied using microscopy. On average, 71% of the early biofilm bacteria were eliminated after 5 min of near infrared radiation (LED emission peak at 850 nm) of the gold nanorod coated surfaces, showing the potential of this novel antibiofilm technique. Most notably, the best individual result showed 97% biofilm elimination. This study demonstrates that nanoplasmonic generated heat offers a novel way of eliminating bacterial biofilms. In future applications, this method may be used to eliminate bacterial contamination during implant surgery.

Nyckelord: Gold nanorods, Localisea surface plasmon resonance, Biofilm, Photothermal therapy, Staphylococcus epiderrnidis

Denna post skapades 2017-10-05. Senast ändrad 2017-10-06.
CPL Pubid: 252343


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Institutionen för kemi och kemiteknik, Teknisk ytkemi



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