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Meta and pooled analysis of European coeliac disease data

Marie-Claude Barbron ; Staffan Nilsson (Institutionen för matematisk statistik) ; Svetlana Adamovic ; Åsa Torinsson Naluai ; Jan Wahlström ; Henry Ascher ; Paul Ciclitera ; Ludvig M Sollid ; Jukka Partanen ; Luigi Greco ; Francoise Clerget-Darpoux
European Journal of Human Genetics (1018-4813). Vol. 11 (2003), 11, p. 828-834.
[Artikel, refereegranskad vetenskaplig]

Four full genome scans have been carried out by the partners of the European cluster on coeliac disease as well as follow-up studies of candidate regions. No region outside HLA showed significant linkage to the disease in any single study. We first applied a meta-analysis based on a modification of Genome Screen Meta-Analysis to take into account the different linkage statistics, the arbitrariness of bin cutoff points, as well as the sample size of each study. We then performed a pooled linkage analysis of all families and raw genotypes. Besides the HLA region, already known to harbour a risk factor for coeliac disease, both approaches leave very little doubt on the presence of a genetic risk factor in the 5q31-33 region. This region was suggested by several individual studies, but did not reach statistical values high enough to be conclusive when data sets were analysed separately.



Denna post skapades 2007-01-09. Senast ändrad 2015-01-16.
CPL Pubid: 25037

 

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Institutioner (Chalmers)

Institutionen för matematisk statistik (2002-2004)
Institutionen för kvinnors och barns hälsa (1991-2005)
Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik (1991-2005)

Ämnesområden

MEDICIN OCH HÄLSOVETENSKAP

Chalmers infrastruktur