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Roles of copper-binding proteins in breast cancer

Stephanie Blockhuys (Institutionen för biologi och bioteknik, Kemisk biologi) ; Pernilla Wittung-Stafshede (Institutionen för biologi och bioteknik, Kemisk biologi)
International Journal of Molecular Sciences (16616596). Vol. 18 (2017), 4, p. Article no 871.
[Artikel, refereegranskad vetenskaplig]

Copper ions are needed in several steps of cancer progression. However, the underlying mechanisms, and involved copper-binding proteins, are mainly elusive. Since most copper ions in the body (in and outside cells) are protein-bound, it is important to investigate what copper-binding proteins participate and, for these, how they are loaded with copper by copper transport proteins. Mechanistic information for how some copper-binding proteins, such as extracellular lysyl oxidase (LOX), play roles in cancer have been elucidated but there is still much to learn from a biophysical molecular viewpoint. Here we provide a summary of copper-binding proteins and discuss ones reported to have roles in cancer. We specifically focus on how copper-binding proteins such as mediator of cell motility 1 (MEMO1), LOX, LOX-like proteins, and secreted protein acidic and rich in cysteine (SPARC) modulate breast cancer from molecular and clinical aspects. Because of the importance of copper for invasion/migration processes, which are key components of cancer metastasis, further insights into the actions of copper-binding proteins may provide new targets to combat cancer.

Nyckelord: ATOX1; Breast cancer; Cancer; Copper transport; Copper-binding protein; Lysyl oxidase; MEMO1; Metastasis]; SPARC

Denna post skapades 2017-06-16. Senast ändrad 2017-10-03.
CPL Pubid: 249949


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Institutioner (Chalmers)

Institutionen för biologi och bioteknik, Kemisk biologi


Biokemi och molekylärbiologi

Chalmers infrastruktur