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Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects

James P. Hall ; Sarah P. Gurung ; Jessica Henle ; Patrick Poidl ; Johanna Andersson (Institutionen för kemi och kemiteknik, Farmaceutisk teknologi) ; Per Lincoln (Institutionen för kemi och kemiteknik, Fysikalisk kemi) ; Graeme Winter ; Thomas Sorensen ; David J. Cardin ; John A. Brazier ; Christine J. Cardin
Chemistry - A European Journal (0947-6539). Vol. 23 (2017), 21, p. 4981-4985.
[Artikel, refereegranskad vetenskaplig]

X-ray crystal structures of three ?-[Ru(L)2dppz]2+ complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2?-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5?-CG-3? step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5?-TA-3? sites. This result suggests that canted intercalation is preferred at 5?-CG-3? sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5?-CG-3? step could give rise to a longer luminescence lifetime than canted intercalation.

Nyckelord: DNA; DNA structures; nucleic acids; structural biology

Denna post skapades 2017-06-14. Senast ändrad 2017-06-21.
CPL Pubid: 249829


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