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Biomimetic Oxidative Carbene Catalysis: Enabling Aerial Oxygen as a Terminal Oxidant

Anton Axelsson (Institutionen för kemi och kemiteknik, Organisk kemi) ; Linda Ta (Institutionen för kemi och kemiteknik, Organisk kemi) ; Henrik Sundén (Institutionen för kemi och kemiteknik, Organisk kemi)
Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry (0936-5214). Vol. 28 (2017), 08, p. 873-878.
[Artikel, refereegranskad vetenskaplig]

Oxidative carbene catalysis is a quickly growing field in organic synthesis. However, these catalytic protocols traditionally rely on the stoichiometric addition of a high-molecular-weight oxidant, providing these reactions with a high E-factor. Here, we review efforts to replace high-molecular-weight oxidants with oxygen using a biomimetic system of coupled electron-transfer mediators. Two reactions are discussed: the aerobic oxidative esterification of aldehydes and the aerobic oxidative NHC-catalyzed enantioselective formation of dihydropyranones.

Nyckelord: NHC - aerobic oxidation - oxygen, biomimetic synthesis, ­organocatalysis, green chemistry, asymmetric synthesis

Denna post skapades 2017-05-03. Senast ändrad 2017-09-14.
CPL Pubid: 249098


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Institutioner (Chalmers)

Institutionen för kemi och kemiteknik, Organisk kemi


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