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MgO implanted in rat tibia bone marrow is osteoinductive through the formation of a matrix, containing hydroxyapatite

H. Nygren ; P. Malmberg ; Yang Liu (Institutionen för kemi och kemiteknik, Analytisk kemi)
Materials Science Forum (02555476 ). Vol. 879 (2017), p. 1404-1407.
[Konferensbidrag, refereegranskat]

Healing of rat tibia after intramedullary implantation of MgO was analysed by Environmental Scanning Electron Microscopy (ESEM) and Energy-Dispersive X-ray spectroscopy (EDX). The results indicated the formation of hydroxyl-apatite (HA) in the entire intramedullary space after 1 week of healing. Then, corroded Mg, MgO and MgCO3 were incubated with DMEM in vitro for 24 h and the surface of the material was analysed by EDX and Time-of-Flight Secondary Ion Mass (ToF-SIMS). The chemical analysis of the Mg corrosion products indicate that HA is formed at the material surface and that MgCO3 was an efficient catalyzer of HA formation. © 2017 Trans Tech Publications, Switzerland.

Nyckelord: Bone cement, Bone healing, Hydroxyl-apatite, Magnesium



Denna post skapades 2017-01-18. Senast ändrad 2017-05-17.
CPL Pubid: 247280

 

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Institutioner (Chalmers)

Institutionen för kemi och kemiteknik, Analytisk kemi

Ämnesområden

Analytisk kemi

Chalmers infrastruktur