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Heme metabolism in stress regulation and protein production: From Cinderella to a key player.

José Luis Martinez Ruiz (Institutionen för biologi och bioteknik, Systembiologi) ; Dina Petranovic (Institutionen för biologi och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för biologi och bioteknik, Systembiologi)
Bioengineered (2165-5987). Vol. 7 (2016), 2, p. 112-5.
[Artikel, refereegranskad vetenskaplig]

Heme biosynthesis is a highly conserved pathway which is present in all kingdoms, from Archaea to higher organisms such as plants and mammals. The heme molecule acts as a prosthetic group for different proteins and enzymes involved in energy metabolism and reactions involved in electron transfer. Based on our recent findings and other recent reports, we here illustrate that heme is more than a co-factor. We also discuss the necessity to gain more insight into the heme biosynthesis pathway regulation, as this interacts closely with overall stress control. Understanding heme biosynthesis and its regulation could impact our ability to develop more efficient yeast cell factories for heterologous protein production.

Nyckelord: Animals, Archaea, metabolism, Heme, biosynthesis, Plants, metabolism, Saccharomyces cerevisiae, metabolism, Saccharomyces cerevisiae Proteins, metabolism

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Denna post skapades 2017-01-17.
CPL Pubid: 247197


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Institutionen för biologi och bioteknik, Systembiologi


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