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Kinetics of enzyme-mediated hydrolysis of lipid vesicles

Vladimir P. Zhdanov (Institutionen för fysik, Biologisk fysik (Chalmers)) ; Björn Agnarsson (Institutionen för fysik, Biologisk fysik (Chalmers)) ; Fredrik Höök (Institutionen för fysik, Biologisk fysik (Chalmers))
Chemical Physics Letters (0009-2614). Vol. 663 (2016), p. 51-56.
[Artikel, refereegranskad vetenskaplig]

Membrane enzymatic reactions can now be experimentally studied at the level of single sub-100 nm lipid vesicles. To interpret such experiments, we scrutinize theoretically various aspects of the hydrolysis of vesicles by single enzyme molecules and enzyme (e.g., PLA2) supplied with the constant rate. Using the mean-field kinetic model, we illustrate the shape of the corresponding kinetics and the dependence of the time scale of the reaction on the vesicle radius. Stochastic effects are illustrated as well. In addition, we discuss the likely mechanisms of the reaction-induced pore formation and bilayer rupture.

Nyckelord: Enzymatic catalysis; Lipid membranes; Mean-field kinetic equations; Monte Carlo simulations; Stochastic kinetics

Denna post skapades 2016-12-19. Senast ändrad 2017-02-06.
CPL Pubid: 246313


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Institutionen för fysik, Biologisk fysik (Chalmers)



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