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Topographically Flat Nanoplasmonic Sensor Chips for Biosensing and Materials Science

Ferry A. A. Nugroho (Institutionen för fysik, Kemisk fysik (Chalmers)) ; Rickard Frost (Institutionen för fysik, Kemisk fysik (Chalmers)) ; Tomasz Antosiewicz (Institutionen för fysik, Bionanofotonik (Chalmers)) ; Joachim Fritzsche (Institutionen för fysik, Kemisk fysik (Chalmers)) ; Elin Larsson Langhammer ; Christoph Langhammer (Institutionen för fysik, Kemisk fysik (Chalmers))
ACS Sensors Vol. 2 (2017), 1, p. 119–127.
[Artikel, refereegranskad vetenskaplig]

Nanoplasmonic sensors typically comprise arrangements of noble metal nanoparticles on a dielectric support. Thus they are intrinsically characterized by surface topography with corrugations at the 10–100 nm length scale. While irrelevant in some bio- and chemosensing applications, it is also to be expected that the surface topography significantly influences the interaction between solids, fluids, nanoparticles and (bio)molecules, and the nanoplasmonic sensor surface. To address this issue, we present a wafer-scale nanolithography-based fabrication approach for high-temperature compatible, chemically inert and topographically flat and laterally homogeneous nanoplasmonic sensor chips. We demonstrate their sensing performance on three different examples, for which we also carry out a direct comparison with a traditional nanoplasmonic sensor with representative surface corrugation. Specifically, we (i) quantify the film-thickness dependence of the glass transition temperature in poly(methyl metacrylate) thin films, (ii) characterize the adsorption and specific binding kinetics of the avidin – b-BSA protein system and (iii) analyze supported lipid bilayer formation on SiO2 surfaces.

Nyckelord: nanoplasmonic sensing (NPS); flat topography; surface corrugation; polymer glass transition; supported lipid bilayer formation; avidin adsorption; b-BSA specific binding

Denna post skapades 2016-12-13. Senast ändrad 2017-09-14.
CPL Pubid: 246074


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Institutioner (Chalmers)

Institutionen för fysik, Kemisk fysik (Chalmers)
Institutionen för fysik, Bionanofotonik (Chalmers)



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