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Non-targeted transcriptomic effects upon thyroid irradiation: similarity between in-field and out-of-field responses varies with tissue type

Britta Langen (Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik ; Sahlgrenska Cancer Center ; Institutionen för fysik (Chalmers)) ; Nils Rudqvist ; Johan Spetz ; Janos Swanpalmer ; Khalil Helou ; Eva Forssell-Aronsson
Scientific Reports (2045-2322). Vol. 6 (2016), p. Article number: 30738.
[Artikel, refereegranskad vetenskaplig]

Non-targeted effects can induce responses in tissues that have not been exposed to ionizing radiation. Despite their relevance for risk assessment, few studies have investigated these effects in vivo. In particular, these effects have not been studied in context with thyroid exposure, which can occur e.g. during irradiation of head and neck tumors. To determine the similarity between in-field and out-offield responses in normal tissue, we used a partial body irradiation setup with female mice where the thyroid region, the thorax and abdomen, or all three regions were irradiated. After 24h, transcriptional regulation in the kidney cortex, kidney medulla, liver, lungs, spleen, and thyroid was analyzed using microarray technology. Thyroid irradiation resulted in transcriptional regulation in the kidney medulla and liver that resembled regulation upon direct exposure of these tissues regarding both strength of response and associated biological function. The kidney cortex showed fewer similarities between the setups, while the lungs and spleen showed little similarity between in-field and out-of-field responses. Interestingly, effects were generally not found to be additive. Future studies are needed to identify the molecular mechanisms that mediate these systemic effects, so that they may be used as targets to minimize detrimental side effects in radiotherapy.



Denna post skapades 2016-10-31. Senast ändrad 2016-12-20.
CPL Pubid: 244479

 

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Institutioner (Chalmers)

Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för radiofysik (GU)
Sahlgrenska Cancer Center (GU)
Institutionen för fysik (Chalmers)
Institutionen för kliniska vetenskaper, sektionen för onkologi, radiofysik, radiologi och urologi, Avdelningen för onkologi (GU)

Ämnesområden

Molekylärbiologi
Bioinformatik och systembiologi
Radiofysik
Strålningsbiologi

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