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Plasma Alkylresorcinols Reflect Gluten Intake and Distinguish between Gluten-Rich and Gluten-Poor Diets in a Population at Risk of Metabolic Syndrome

Mads Vendelbo Lind (Institutionen för biologi och bioteknik, Livsmedelsvetenskap) ; M. L. Madsen ; J. J. Rumessen ; H. Vestergaard ; R. J. Gabel ; T. Hansen ; L. Lauritzen ; O. B. Pedersen ; M. Kristensen ; Alastair Ross (Institutionen för biologi och bioteknik, Livsmedelsvetenskap)
Journal of Nutrition (0022-3166). Vol. 146 (2016), 10, p. 1991-1998.
[Artikel, refereegranskad vetenskaplig]

Background: Many patients with celiac disease experience difficulties in adherence to a gluten-free diet. Methods for testing compliance to a gluten-free diet are costly and cumbersome. Thus, a simple biomarker of gluten intake is needed in a clinical setting and will be useful for epidemiologic studies investigating wider effects of gluten intake. Objective: The aim was to evaluate plasma total alkylresorcinol concentrations as a measure of gluten intake. Methods: In this randomized, controlled, crossover intervention study in 52 Danish adults with features of the metabolic syndrome, we compared 8 wk of a gluten-rich and gluten-poor diet separated by a washout period of wk. We measured fasting plasma concentrations of alkylresorcinols to determine if they reflected differences in gluten intake as a secondary outcome of the original study. In addition, we investigated in 118 Danish adults the cross-sectional association between self reported gluten intake and plasma alkylresorcinols in the same and a similar study at baseline. We used mixed-model ANCOVA for examining treatment effects, a classification tree to determine compliance to the gluten-poor diet, and linear regression models for examining baseline correlation between plasma alkylresorcinol concentrations and gluten intake. Results: Plasma total alkylresorcinols decreased more during the gluten-poor period (geometric mean: -124.8 nmol/L; 95% CI: -156.5, -93.0 nmol/L) than in the gluten-rich period (geometric mean: -31.8 nmol/L; 95% CI: -63.1, -0.4 nmol/L) (P < 0.001). On the basis of the plasma alkylresorcinol profile, we built a classification tree to objectively determine compliance and found an overall participant misclassification error of 3.9%. In the cross-sectional study we found a 5.6% (95% CI: 2.4%, 8.9%) increase in plasma total alkylresorcinols per 1-g increase in reported gluten intake (P < 0.001). Conclusion: We propose the use of plasma alkylresorcinols to monitor compliance to a gluten-free diet as well as to help investigations into the possible effects of gluten in the wider population. This trial was registered at www.clinicaltrials.gov as NCT017119913 and NCT01731366.

Nyckelord: celiac disease, biomarkers, gluten sensitivity, gluten-related disorders, coeliac disease, gluten, whole-grain wheat, celiac-disease, rye intake, electrochemical, detection, liquid-chromatography, cereal-grains, at-risk, prevalence, adults, adolescents

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Denna post skapades 2016-10-28. Senast ändrad 2017-10-31.
CPL Pubid: 244424


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