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Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection

Erika Ahlgren ; Lars Hagberg ; Dietmar Fuchs ; Lars-Magnus Andersson ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Henrik Zetterberg ; Magnus Gisslén
PLoS ONE (1932-6203). Vol. 11 (2016), 7, p. e0158973.
[Artikel, refereegranskad vetenskaplig]

Objective To investigate the role of homocysteine in neuronal injury in HIV infection. Methods Using a cross-sectional design and archived samples, we compared concentrations of plasma homocysteine and cerebrospinal fluid (CSF) neurofilament light protein (NFL), a sensitive marker of neuronal injury, in 83 HIV-1-infected subjects without antiretroviral treatment. We also analyzed plasma vitamin B12, serum folate, CSF, and plasma HIV RNA, the immune activation marker neopterin in CSF and serum, and albumin ratio as a marker of blood-brain barrier integrity. Twenty-two subjects provided a second sample median of 12.5 months after antiretroviral treatment initiation. Results A significant correlation was found between plasma homocysteine and CSF NFL concentrations in untreated individuals (r = 0.52, p < 0.0001). As expected, there was a significant inverse correlation between homocysteine and B12 (r = -0.41, p < 0.001) and folate (r = -0.40, p = < 0.001) levels. In a multiple linear regression analysis homocysteine stood out as an independent predictor of CSF NFL in HIV-1-infected individuals. The correlation of plasma homocysteine and CSF NFL was also present in the group receiving antiretroviral therapy (r = 0.51, p = 0.016). Conclusion A correlation between plasma homocysteine and axonal injury, as measured by CSF NFL, was found in both untreated and treated HIV. While this study is not able to prove a causal link, homocysteine and functional B12/folate deficiency appear to play a role in neural injury in HIV-infected individuals.



Denna post skapades 2016-09-07. Senast ändrad 2016-10-04.
CPL Pubid: 241442

 

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Institutioner (Chalmers)

Institutionen för biomedicin, avdelningen för infektionssjukdomar (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (GU)

Ämnesområden

Neurokemi

Chalmers infrastruktur