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Eicosapentaenoic and Docosahexaenoic Acid-Enriched High Fat Diet Delays Skeletal Muscle Degradation in Mice

Soni Nikulkumar (Institutionen för biologi och bioteknik, Livsmedelsvetenskap) ; Alastair Ross (Institutionen för biologi och bioteknik, Livsmedelsvetenskap) ; Nathalie Scheers (Institutionen för biologi och bioteknik, Livsmedelsvetenskap) ; Otto Savolainen (Institutionen för biologi och bioteknik, Livsmedelsvetenskap) ; Intawat Nookaew (Institutionen för biologi och bioteknik, Systembiologi) ; Britt G. Gabrielsson (Institutionen för biologi och bioteknik, Livsmedelsvetenskap) ; Ann-Sofie Sandberg (Institutionen för biologi och bioteknik, Livsmedelsvetenskap)
Nutrients (2072-6643). Vol. 8 (2016), 9, p. 543.
[Artikel, refereegranskad vetenskaplig]

Low-grade chronic inflammatory conditions such as ageing, obesity and related metabolic disorders are associated with deterioration of skeletal muscle (SkM). Human studies have shown that marine fatty acids influence SkM function, though the underlying mechanisms of action are unknown. As a model of diet-induced obesity, we fed C57BL/6J mice either a high fat diet (HFD) with purified marine fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (HFD-ED), a HFD with corn oil, or normal mouse chow for 8 weeks; and used transcriptomics to identify the molecular effects of EPA and DHA on SkM. Consumption of ED-enriched HFD modulated SkM metabolism through increased gene expression of mitochondrial β-oxidation and slow-fiber type genes compared with HFD-corn oil fed mice. Furthermore, HFD-ED intake increased nuclear localization of nuclear factor of activated T-cells (Nfatc4) protein, which controls fiber-type composition. This data suggests a role for EPA and DHA in mitigating some of the molecular responses due to a HFD in SkM. Overall, the results suggest that increased consumption of the marine fatty acids EPA and DHA may aid in the prevention of molecular processes that lead to muscle deterioration commonly associated with obesity-induced low-grade inflammation.

Nyckelord: eicosapentaenoic acid (EPA)/Docosahexaenoic acid (DHA), obesity, skeletal-muscle metabolism, mitochondrial β-oxidation, transcriptome

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Denna post skapades 2016-09-05. Senast ändrad 2017-06-27.
CPL Pubid: 241307


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