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Increased Intrathecal Immune Activation in Virally Suppressed HIV-1 Infected Patients with Neurocognitive Impairment

Arvid Edén ; T. D. Marcotte ; R. K. Heaton ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Henrik Zetterberg ; D. Fuchs ; D. Franklin ; R. W. Price ; I. Grant ; S. L. Letendre ; Magnus Gisslén
Plos One (1932-6203). Vol. 11 (2016), 6, p. 0157160.
[Artikel, refereegranskad vetenskaplig]

Objective Although milder forms of HIV-associated neurocognitive disorder (HAND) remain prevalent, a correlation to neuronal injury has not been established in patients on antiretroviral therapy (ART). We examined the relationship between mild HAND and CSF neurofilament light protein (NFL), a biomarker of neuronal injury; and CSF neopterin, a biomarker of CNS immunoactivation, in virally suppressed patients on antiretroviral therapy (ART). We selected 99 subjects on suppressive ART followed longitudinally from the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) study. Based on standardized comprehensive neurocognitive performance (NP) testing, subjects were classified as neurocognitively normal (NCN; n = 29) or impaired (NCI; n = 70). The NCI group included subjects with asymptomatic (ANI; n = 37) or mild (MND; n = 33) HAND. CSF biomarkers were analyzed on two occasions. Geometric mean CSF neopterin was 25% higher in the NCI group (p = 0.04) and NFL and neopterin were significantly correlated within the NCI group (r = 0.30; p<0.001) but not in the NCN group (r = -0.13; p = 0.3). Additionally, a trend towards higher NFL was seen in the NCI group (p = 0.06). Mild HAND was associated with increased intrathecal immune activation, and the correlation between neopterin and NFL found in NCI subjects indicates an association between neurocognitive impairment, CNS inflammation and neuronal damage. Together these findings suggest that NCI despite ART may represent an active pathological process within the CNS that needs further characterization in prospective studies.

Nyckelord: cerebrospinal-fluid neopterin, central-nervous-system, antiretroviral, therapy, neurofilament protein, hiv-1 infection, deficit scores, disorders, csf, prevalence, biomarkers


Article Number: e0157160



Denna post skapades 2016-08-09. Senast ändrad 2016-08-26.
CPL Pubid: 240034

 

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Institutioner (Chalmers)

Institutionen för biomedicin, avdelningen för infektionssjukdomar (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (GU)

Ämnesområden

Infektionsmedicin

Chalmers infrastruktur