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Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels

Erik Sörstedt ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; A. Blaxhult ; Magnus Gisslén ; L. Flamholc ; A. Sonnerborg ; Aylin Yilmaz
BMC Infectious Diseases (1471-2334). Vol. 16 (2016), p. article number 305.
[Artikel, refereegranskad vetenskaplig]

Background: Many HIV-1-infected patients on suppressive antiretroviral therapy (ART) have transiently elevated HIV RNA levels. The clinical significance of these viral blips is uncertain. We have determined the incidence of blips and investigated important associations in the Swedish HIV-cohort. Methods: HIV-1-infected ART naive adults who commenced ART 2007-2013 were retrospectively included. Viral blips were defined as a transient viral load between 50 and 500 copies/mL Subjects not suppressed after six months on ART were excluded. Results: Viral blips were found in 76/735 included subjects (10.3 %) and in 90/4449 samples (2.0 %). Median blip viral load was 76 copies/mL (range 56-138). Median follow-up time was 170 weeks (range 97-240). Baseline viral load was higher in subjects with viral blips (median log(10) 4.85 copies/mL) compared with subjects without blips (median log(10) 4.55 copies/mL) (p < 0.01). There was a significant association between viral blips and risk for subsequent virological failure (p < 0.001). Conclusions: The Swedish national HIV-cohort has a low incidence of viral blips (10 %). Blips were associated with high baseline viral load and an increased risk of subsequent virological failure.

Nyckelord: Viral blip, Transient viremia, HIV-1, Antiretroviral therapy



Denna post skapades 2016-07-25. Senast ändrad 2016-09-09.
CPL Pubid: 239470

 

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Institutioner (Chalmers)

Institutionen för biomedicin, avdelningen för infektionssjukdomar (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)

Ämnesområden

Infektionsmedicin

Chalmers infrastruktur