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Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer's disease treatment

Joana A. Loureiro ; Bárbara Gomes ; Gert Fricker ; Manuel A N Coelho ; Sandra Rocha (Institutionen för biologi och bioteknik, Kemisk biologi) ; Maria Carmo Pereira
Colloids and Surfaces B: Biointerfaces (0927-7765). Vol. 145 (2016), p. 8-13.
[Artikel, refereegranskad vetenskaplig]

During the last few decades, relevant efforts have been reported to design nanocarriers for drug transport through the blood brain barrier (BBB). New drugs, such as peptide iA?5, capable to inhibit the aggregates associated with Alzheime?s disease (AD) are being tested but the most frequent drawback is to reach the brain in the desired concentrations due to the low BBB permeability-surface area. Our approach, as a proof of concept to improve drug transport through the BBB, is based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles with surface functionalized with anti-transferrin receptor monoclonal antibody (OX26) and anti-A? (DE2B4) to deliver encapsulated iA?5 into the brain. Porcine brain capillary endothelial cells (PBCECs) were used as a BBB model to evaluate the system efficacy and toxicity. The uptake of immune nanoparticles with a controlled delivery of the peptide iA?5 was substantially increased compared to the nanoparticles (NPs) without monoclonal antibody functionalization.

Nyckelord: Alzheimer's disease; Antibodies; Blood brain-barrier; Drug delivery systems; Immuno nanoparticles; Therapeutic peptides

Denna post skapades 2016-07-11. Senast ändrad 2016-10-19.
CPL Pubid: 239228


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Institutionen för biologi och bioteknik, Kemisk biologi



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