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Transcriptomics resources of human tissues and organs

M. Uhlen ; B. M. Hallstrom ; C. Lindskog ; Adil Mardinoglu (Institutionen för biologi och bioteknik, Systembiologi) ; F. Ponten ; Jens B. Nielsen (Institutionen för biologi och bioteknik, Systembiologi)
Molecular Systems Biology (1744-4292). Vol. 12 (2016), 4,
[Artikel, refereegranskad vetenskaplig]

Quantifying the differential expression of genes in various human organs, tissues, and cell types is vital to understand human physiology and disease. Recently, several large-scale transcriptomics studies have analyzed the expression of protein-coding genes across tissues. These datasets provide a framework for defining the molecular constituents of the human body as well as for generating comprehensive lists of proteins expressed across tissues or in a tissue-restricted manner. Here, we review publicly available human transcriptome resources and discuss body-wide data from independent genome-wide transcriptome analyses of different tissues. Gene expression measurements from these independent datasets, generated using samples from fresh frozen surgical specimens and postmortem tissues, are consistent. Overall, the different genome-wide analyses support a distribution in which many proteins are found in all tissues and relatively few in a tissue-restricted manner. Moreover, we discuss the applications of publicly available omics data for building genome-scale metabolic models, used for analyzing cell and tissue functions both in physiological and in disease contexts.

Nyckelord: genome-scale metabolic models, proteomics, transcriptomics

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Denna post skapades 2016-06-10. Senast ändrad 2016-07-05.
CPL Pubid: 237575


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Institutioner (Chalmers)

Institutionen för biologi och bioteknik, Systembiologi


Bioinformatik och systembiologi

Chalmers infrastruktur