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Model-based optimization and scale-up of multi-feed simultaneous saccharification and co-fermentation of steam pre-treated lignocellulose enables high gravity ethanol production.

Ruifei Wang (Institutionen för biologi och bioteknik, Industriell bioteknik) ; Pornkamol Unrean (Institutionen för biologi och bioteknik, Industriell bioteknik) ; Carl Johan Franzén (Institutionen för biologi och bioteknik, Industriell bioteknik)
Biotechnology for biofuels (1754-6834). Vol. 9 (2016), p. 88.
[Artikel, refereegranskad vetenskaplig]

High content of water-insoluble solids (WIS) is required for simultaneous saccharification and co-fermentation (SSCF) operations to reach the high ethanol concentrations that meet the techno-economic requirements of industrial-scale production. The fundamental challenges of such processes are related to the high viscosity and inhibitor contents of the medium. Poor mass transfer and inhibition of the yeast lead to decreased ethanol yield, titre and productivity. In the present work, high-solid SSCF of pre-treated wheat straw was carried out by multi-feed SSCF which is a fed-batch process with additions of substrate, enzymes and cells, integrated with yeast propagation and adaptation on the pre-treatment liquor. The combined feeding strategies were systematically compared and optimized using experiments and simulations.

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Denna post skapades 2016-05-12. Senast ändrad 2016-05-27.
CPL Pubid: 236379


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