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Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution

L. Pedersen ; M. Idorn ; G. H. Olofsson ; B. Lauenborg ; Intawat Nookaew (Institutionen för biologi och bioteknik, Systembiologi) ; R. H. Hansen ; H. H. Johannesen ; J. C. Becker ; K. S. Pedersen ; C. Dethlefsen ; Jens B. Nielsen (Institutionen för biologi och bioteknik, Systembiologi) ; J. Gehl ; B. K. Pedersen ; P. T. Straten ; P. Hojman
Cell Metabolism (1550-4131). Vol. 23 (2016), 3, p. 554-562.
[Artikel, refereegranskad vetenskaplig]

Regular exercise reduces the risk of cancer and disease recurrence. Yet the mechanisms behind this protection remain to be elucidated. In this study, tumor-bearing mice randomized to voluntary wheel running showed over 60% reduction in tumor incidence and growth across five different tumor models. Microarray analysis revealed training-induced up-regulation of pathways associated with immune function. NK cell infiltration was significantly increased in tumors from running mice, whereas depletion of NK cells enhanced tumor growth and blunted the beneficial effects of exercise. Mechanistic analyses showed that NK cells were mobilized by epinephrine, and blockade of beta-adrenergic signaling blunted training-dependent tumor inhibition. Moreover, epinephrine induced a selective mobilization of IL-6-sensitive NK cells, and IL-6-blocking antibodies blunted training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation. Together, these results link exercise, epinephrine, and IL-6 to NK cell mobilization and redistribution, and ultimately to control of tumor growth.

Nyckelord: missing-self-recognition, natural-killer-cells, physical-activity, cancer, exercise, il-6, muscle, inflammation, phenotype, cytokines



Denna post skapades 2016-05-04. Senast ändrad 2016-05-12.
CPL Pubid: 235939

 

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Institutioner (Chalmers)

Institutionen för biologi och bioteknik, Systembiologi

Ämnesområden

Cellbiologi

Chalmers infrastruktur