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Effects of Al3+ on Phosphocholine and Phosphoglycerol Containing Solid Supported Lipid Bilayers

H. K. Wayment-Steele ; Yujia Jing (Institutionen för fysik, Biologisk fysik (Chalmers)) ; M. J. Swann ; L. E. Johnson ; Björn Agnarsson (Institutionen för fysik, Biologisk fysik (Chalmers)) ; Sofia Svedhem (Institutionen för fysik, Biologisk fysik (Chalmers)) ; M. S. Johal ; Angelika Kunze (Institutionen för fysik, Biologisk fysik (Chalmers))
Langmuir (0743-7463). Vol. 32 (2016), 7, p. 1771-1781.
[Artikel, refereegranskad vetenskaplig]

Aluminum has attracted great attention recently as it has been suggested by several studies to be associated with increased risks for Alzheimer's and Parkinson's disease. The toxicity of the trivalent ion is assumed to derive from structural changes induced in lipid bilayers upon binding, though the mechanism of this process is still not well understood. In the present study we elucidate the effect of Al3+ on supported lipid bilayers (SLBs) using fluorescence microscopy, the quartz crystal microbalance with dissipation (QCM-D) technique, dual-polarization interferometry (DPI), and molecular dynamics (MD) simulations. Results from these techniques show that binding of Al3+ to SLBs containing negatively charged and neutral phospholipids induces irreversible changes such as domain formation. The measured variations in SLB thickness, birefringence, and density indicate a phase transition from a disordered to a densely packed ordered phase.

Denna post skapades 2016-03-23. Senast ändrad 2016-06-30.
CPL Pubid: 233639


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