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Estimation of body fluids with bioimpedance spectroscopy: state of the art methods and proposal of novel methods

Ruben Buendia (Institutionen för signaler och system, Medicinska signaler och system) ; Fernando Seoane ; Kaj Lindecrantz ; Ingvar Bosaeus ; R. Gil-Pita ; Gudmundur Johannsson ; Lars Ellegård ; L. C. Ward
Physiological Measurement (0967-3334). Vol. 36 (2015), 10, p. 93.
[Artikel, refereegranskad vetenskaplig]

Determination of body fluids is a useful common practice in determination of disease mechanisms and treatments. Bioimpedance spectroscopy (BIS) methods are non-invasive, inexpensive and rapid alternatives to reference methods such as tracer dilution. However, they are indirect and their robustness and validity are unclear. In this article, state of the art methods are reviewed, their drawbacks identified and new methods are proposed. All methods were tested on a clinical database of patients receiving growth hormone replacement therapy. Results indicated that most BIS methods are similarly accurate (e.g. < 0.5 +/- 3.0% mean percentage difference for total body water) for estimation of body fluids. A new model for calculation is proposed that performs equally well for all fluid compartments (total body water, extra-and intracellular water). It is suggested that the main source of error in extracellular water estimation is due to anisotropy, in total body water estimation to the uncertainty associated with intracellular resistivity and in determination of intracellular water a combination of both.

Nyckelord: bioimpedance, body composition, body fluids estimation



Denna post skapades 2016-03-02. Senast ändrad 2016-04-07.
CPL Pubid: 232680

 

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Institutioner (Chalmers)

Institutionen för signaler och system, Medicinska signaler och system
Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition (GU)

Ämnesområden

Invärtesmedicin
Biomedicinsk laboratorievetenskap/teknologi

Chalmers infrastruktur