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Two approaches to study structural identifiability analysis in mixed-effects models

David Janzén ; Mats Jirstrand (Institutionen för biologi och bioteknik, Systembiologi ; Institutionen för signaler och system, Reglerteknik) ; Michael J. Chappell ; Neil D. Evans
Proceedings of Pharmacokinetics UK (PKUK) 2015 p. 38. (2015)
[Konferensbidrag, poster]

A prerequisite for a well-posed inference problem is that there exists a unique solution for any given input-output relation. Such a model is said to be structurally globally identifiable. If there are several solutions or an infinite number of solutions the model is said to be structurally locally identifiable or structurally unidentifiable respectively. Structural identifiability is an important concept as parameter estimates from a structurally unidentifiable model are effectively meaningless. In practice this means that if for instance a clearance parameter CL is structurally unidentifiable, it means that the parameter CL can have any arbitrarily numerical value and the model will still be able to fit the available experimental data. For a system defined by ordinary differential equations there exist several techniques to determine whether the model is structurally identifiable or otherwise. However for mixed-effect models the identifiability concept is still very much unexplored. Because of this very little has been done on development of such techniques, despite mixed-effects modelling being a well-used modelling approach.



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Denna post skapades 2016-01-18.
CPL Pubid: 230867