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Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.

Martin Adiels ; Adil Mardinoglu (Institutionen för biologi och bioteknik, Systembiologi) ; Marja-Riitta Taskinen ; Jan Borén
Frontiers in Physiology (1664-042X). Vol. 6 (2015), p. 342.
[Artikel, refereegranskad vetenskaplig]

To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.

Nyckelord: very low density lipoproteins, apoB, multocomnpartmental modeling, kinetics, stable isotopes



Denna post skapades 2015-12-22. Senast ändrad 2016-01-15.
CPL Pubid: 228899

 

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Institutioner (Chalmers)

Institutionen för medicin, avdelningen för molekylär och klinisk medicin (GU)
Hälsometri (GU)
Wallenberglaboratoriet (GU)
Institutionen för biologi och bioteknik, Systembiologi

Ämnesområden

Bioinformatik (beräkningsbiologi)
Bioinformatik och systembiologi
Medicinska grundvetenskaper
Klinisk medicin

Chalmers infrastruktur