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Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals

David Jullesson (Institutionen för biologi och bioteknik, Systembiologi) ; Florian David (Institutionen för biologi och bioteknik, Systembiologi) ; B. Pfleger ; Jens B. Nielsen (Institutionen för biologi och bioteknik, Systembiologi)
Biotechnology Advances (0734-9750). Vol. 33 (2015), 7, p. 1395-1402.
[Artikel, refereegranskad vetenskaplig]

© 2015 Elsevier Inc. Industrial bio-processes for fine chemical production are increasingly relying on cell factories developed through metabolic engineering and synthetic biology. The use of high throughput techniques and automation for the design of cell factories, and especially platform strains, has played an important role in the transition from laboratory research to industrial production. Model organisms such as Saccharomyces cerevisiae and Escherichia coli remain widely used host strains for industrial production due to their robust and desirable traits. This review describes some of the bio-based fine chemicals that have reached the market, key metabolic engineering tools that have allowed this to happen and some of the companies that are currently utilizing these technologies for developing industrial production processes.

Nyckelord: Cell factories, Escherichia coli, Industrial production, Metabolic engineering, Saccharomyces cerevisiae, Synthetic biology



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Denna post skapades 2015-11-30. Senast ändrad 2017-01-17.
CPL Pubid: 226535

 

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