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Human Milk: Its Components and Their Immunobiologic Functions

Dulal Ravi Sharma (Institutionen för mikroteknologi och nanovetenskap, Kvantkomponentfysik) ; Lars Åke Hanson ; Marina Korotkova ; Esbjörn Telemo ; P. Ogra
Mucosal Immunology: Fourth Edition. Volume 2 Vol. 2-2 (2015), p. 2307-2341.

Whereas a neonate is born is sterile, immediate exposure to its mother's mucosal surfaces allows it to acquire microflora, which plays an important role in defense against potential pathogens. This initial stimulus helps the immature immune system of the newborn to develop the capacity to respond with specific immunologic tolerance while avoiding the development of allergic and autoimmune disease. Breast-feeding provides nutritional and developmental, along with anti-infectious, advantages to the infant. The significant protection conferred by breast-feeding against varied infections such as acute and prolonged diarrhea, neonatal septicemia, respiratory tract infections, acute and recurrent otitis media, and urinary tract infections is observed worldwide. Human breast milk contains numerous components, including antibodies, cytokines, hormones, enzymes, and major proteins with multiple activities (microbicidal, tumoricidal, anti-inflammatory, autoimmune, etc.). Breast-feeding can strikingly reduce infant mortality, as well as the fertility of the breast-feeding mother. In this manner, breast-feeding provides significant benefits for lactating mothers and their offspring, in addition to society as a whole. © 2015 Elsevier Inc. All rights reserved.

Nyckelord: Anti-inflammatory, Atopy, Human milk, Infant mortality, Microbicidal, Neonate, Obesity, Tumoricidal

Denna post skapades 2015-11-23. Senast ändrad 2015-11-27.
CPL Pubid: 226165


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Institutioner (Chalmers)

Institutionen för mikroteknologi och nanovetenskap, Kvantkomponentfysik
Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi (GU)
Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa (GU)
Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning (GU)


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