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Differences in anxiety-like behavior within a batch of wistar rats are associated with differences in serotonergic transmission, enhanced by acute sri administration, and abolished by serotonin depletion

Jakob Näslund ; Erik Studer ; Robert Pettersson ; S Melker Hagsäter ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Hans Nissbrandt ; Elias Eriksson
International Journal of Neuropsychopharmacology (1461-1457). Vol. 18 (2015), 8, p. 1-9.
[Artikel, refereegranskad vetenskaplig]

Background: The anxiety-reducing effect of long-term administration of serotonin reuptake inhibitors is usually seen only in subjects with anxiety disorders, and such patients are also abnormally inclined to experience a paradoxical anxietyenhancing effect of acute serotonin reuptake inhibition. These unique responses to serotonin reuptake inhibitors in anxietyprone subjects suggest, as do genetic association studies, that inter-individual differences in anxiety may be associated with differences in serotonergic transmission. Methods: The one-third of the animals within a batch of Wistar rats most inclined to spend time on open arms in the elevated plus maze were compared with the one-third most inclined to avoid them with respect to indices of brain serotonergic transmission and how their behavior was influenced by serotonin-modulating drugs. Results: "Anxious" rats displayed higher expression of the tryptophan hydroxylase-2 gene and higher levels of the tryptophan hydroxylase-2 protein in raphe and also higher levels of serotonin in amygdala. Supporting these differences to be important for the behavioral differences, serotonin depletion obtained by the tryptophan hydroxylase-2 inhibitor p-chlorophenylalanine eliminated them by reducing anxiety in "anxious" but not "non-anxious" rats. Acute administration of a serotonin reuptake inhibitor, paroxetine, exerted an anxiety-enhancing effect in "anxious" but not "non-anxious" rats, which was eliminated by long-term pretreatment with another serotonin reuptake inhibitor, escitalopram. Conclusions: Differences in an anxiogenic impact of serotonin, which is enhanced by acute serotonin reuptake inhibitor administration, may contribute to differences in anxiety-like behavior amongst Wistar rats..

Nyckelord: Anxiety, Elevated Plus Maze, Serotonin, Serotonin Reuptake Inhibitors, Tryptophan Hydroxylase 2



Denna post skapades 2015-07-06. Senast ändrad 2015-07-06.
CPL Pubid: 219499

 

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Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)

Ämnesområden

Farmakologi och toxikologi

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