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Enabling Technologies to Advance Microbial Isoprenoid Production

Yun Chen (Institutionen för biologi och bioteknik, Systembiologi) ; Yongjin Zhou (Institutionen för biologi och bioteknik, Systembiologi) ; Verena Siewers (Institutionen för biologi och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för biologi och bioteknik, Systembiologi)
Advances in Biochemical Engineering/Biotechnology (0724-6145). Vol. 148 (2015), p. 143-160.
[Artikel, refereegranskad vetenskaplig]

Microbial production of isoprenoids provides an attractive alternative to biomass extraction and chemical synthesis. Although widespread research aims for isoprenoid biosynthesis, it is still in its infancy in terms of delivering commercial products. Large barriers remain in realizing a cost-competitive process, for example, developing an optimal microbial cell factory. Here, we summarize the many tools and methods that have been developed in the metabolic engineering of isoprenoid production, with the advent of systems biology and synthetic biology, and discuss how these technologies advance to accelerate the design–build–test engineering cycle to obtain optimum microbial systems. It is anticipated that innovative combinations of new and existing technologies will continue to emerge, which will enable further development of microbial cell factories for commercial isoprenoid production.

Nyckelord: E. coli, Enabling technologies, Metabolic engineering, S. cerevisiae, Sesquiterpenes, Terpenoids



Denna post skapades 2015-06-23. Senast ändrad 2016-05-26.
CPL Pubid: 218720

 

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Institutioner (Chalmers)

Institutionen för biologi och bioteknik, Systembiologi

Ämnesområden

Biologiska vetenskaper

Chalmers infrastruktur