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Biodegradable nanofilms on microcapsules for controlled release of drugs to infected chronic wounds

Marina Craig (Institutionen för kemi och kemiteknik, Teknisk ytkemi ; SuMo Biomaterials) ; Erich Schuster ; Krister Holmberg (Institutionen för kemi och kemiteknik, Teknisk ytkemi)
Materials Today: Proceedings (2214-7853). Vol. 1 (2015), p. 118-125.
[Artikel, refereegranskad vetenskaplig]

Systemic antibiotic and topical antimicrobial overexposure strongly contributes to the development of bacterial resistance. We have assembled nanofilms as a lid for drugs, which respond to the Staphylococcus aureus protease V8, while remaining intact when exposed to a human wound protease. Hollow microcapsules, loaded with a model drug and with the nanofilm as shell were assembled by template assisted assembly. With a poly-L-glutamic acid-based film, the Glu-X specific V8 caused the film to degrade, leading to release of the model drug, while the human wound protease did not affect the microcapsules. This is an example of triggered release of an active with the wound infection being the trigger.

Nyckelord: Nanofilm; polyelectrolyte; microcapsule; controlled release; enzymatic degradation; infection; Staphylococcus aureus

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Denna post skapades 2015-06-11. Senast ändrad 2016-07-15.
CPL Pubid: 218209


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Institutioner (Chalmers)

Institutionen för kemi och kemiteknik, Teknisk ytkemi
SuMo Biomaterials



Chalmers infrastruktur

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Bacteria-responsive materials for drug delivery